R01-MH40859 (P.I. C. Hendricks Brown)
This is the continuation of a previous grant entitled Statistical Methods for Mental Health Preventative Trials, and is in its 17th year of funding (no-cost extension year). The project involves developing designs and analytical methods (1) to handle selection bias, variations in implementation, participation, and adherence, and differential attrition in preventive trials, (2) to develop efficient designs for preventive trials addressing questions of efficacy as well as effectiveness, implementation, dissemination and scalability, and (3) to merge biostatistical, psychometric, and epidemiologic methods regarding intervention impact, to elucidate variation in intervention impact.
R01-MH42968 (P.I. Sheppard Kellam)
This proposal extends the follow-up of two cohorts of 2311 Baltimore children, now in late adolescence, who comprised the study sample for a randomized field trial of two classroom interventions in first and second grade. These interventions focused on improving learning and improving classroom behavior, particularly lessening aggression, two risk factors for later depressive symptoms and conduct disorder. This study models developmental course in relevant social fields throughout most of childhood and adolescence, and examines the consequences of successfully improving or failing to improve early in life the consequences of successfully improving or failing to improve early in life.
5T32MH018834 (P.I. Nick Ialongo)
This is a training grant proposal from the Baltimore Prevention Research Center housed at the Department of Mental Hygiene, Johns Hopkins University. The proposal involves a collaborative training effort with prevention scientists and statistical methodologists to train post-doctoral fellows in the field of prevention. Special attention is planned for recruiting and training fellows who have doctorates in statistics or a closely related field.
1R01DA015409 (P.I. Sheppard Kellam)
This is a third generation preventive field trial of a classroom-based intervention aimed at early risk factors for substance abuse. The intervention aims at enhancing reading, through improved curriculum, training, and coaching, at aggressive/disruptive behavior through the Good Behavior Game and other classroom management techniques, and through a parent-teacher partnership. There are three phases to this study, an effectiveness trial for the first cohort, which is followed through third grade, a sustainability trial examining impact in second and third cohorts, and a scalability trial examining how impact is affected when the intervention is expanded to whole schools.
3R01MH040859-15S1 (C. Hendricks Brown) 2002-2004
A National Institute of Mental Health supplement to support a feasibility study of the prevention of using existing preventive field trials aimed at adolescent drug abuse, conduct disorder, and mental health outcomes to examine their potential impact on prevention of suicide through young adulthood. As a feasibility study, we are using three carefully designed randomized field trials to test whether appropriate IRB and HIPAA compliance can be met, and then identifying cause of death among those randomized using the National Death Index. This project also supports developing methodology for examining impact of population-based prevention programs on low base rate disorders.
3R01 MH40859- MH8429808 (C Hendricks Brown)
Centers for Disease Control and Prevention supplement to Designs and Analyses for Mental Health Preventive Trials extends the work on methodology for population-based approaches to the prevention of suicide. This supports the collection and summarizing of national death indexes and to develop the methodology for meta-analytic follow-up studies. This new methodology involves collecting new data across multiple studies, such as cause of death and analyzing interventions’ overall and varying effects across a range of distinct trials.
3P30 MH46690-13S1 (Getachew A. Dagne)
This supplement grant is for theoretical training in social interaction and preventive intervention theories, and developing new methods for analyzing behavioral observations data, in collaboration with the Oregon Prevention Research Center (OPRC), at the Oregon Social Learning Center, Eugene.
R34MH071189-01 (P.I. Peter Wyman)
This R34 application to the National Institute of Mental Health is for testing with a randomized school-based trial a model of gatekeeper training of all staff in 32 middle and high schools in a school district in Georgia. The QPR training program is provided in a wait-listed design to all schools. Working closely with the school’s Prevention Intervention Center, we will evaluate whether more children with suicidal ideation and behaviors are identified, get professionally assessed and enter treatment. Levels of suicidal ideation in 8th and 10th grades are also examined.
(C. Hendricks Brown)
A competing continuation of the primary R01 that has supported the Prevention Science and Methodology Group (Designs and Analyses for Mental Health Preventive Trials MH40859). These aims extend the current work by developing an integrated set of new statistical models, Multilevel Growth Mixture Models, that incorporate person-level, time, and context in the same methodology. We also present new statistical designs for randomized field trials and incorporate nonlinear “additive” models. A second aim focuses on designs and analyses for low base rate disorders, including suicide, psychosis, and drug abuse/dependence. The third aim will focus on the designs and analyses specifically appropriate for implementing interventions with communities. We will develop new designs for implementation trials, including trials outside a trial and trials after a trial.
(P.I. C. Hendricks Brown)
This application to the National Institute on Drug Abuse is for the
establishment of the Ed/Prev Training Center, a cross-site, transdisciplinary-predoctoral
and postdoctoral training program to integrate education and prevention
research in schools. The research groups involved in this application are
the Prevention Science and Methodology Group (PSMG), directed from the
University of South Florida (USF; Brown) and UCLA (Muthén), the
Center for Integrating Education and Prevention Research in Schools (Ed/Prev
Center for short), directed from the American Institutes of Research (AIR,
Kellam, Poduska), USF (Brown), and the Oregon Social Learning Center (OSLC;
Reid), and the Oregon Prevention Research Center, directed from OSLC (Reid)
with collaboration from PSMG (Brown). Through a cross-site training program,
we will provide to trainees 1) a diverse pool of randomized field trials
at different phases of development from which to learn how to develop partnerships
and interventions, design and implement trials, and analyze data; and 2)
a transdisciplinary approach to conduct cutting edge prevention science.
This application represents a collective vision for public health and
population-oriented approaches to preventing suicide and attempted suicide,
and the morbidity arising from myriad associated risk factors. The
PHP-Center aims to build a unique, multidisciplinary research enterprise
that will provide an intellectual epicenter for the developing field of
suicide prevention; initiate a scientifically-oriented Suicide Prevention
and Public Mental Health annual meeting; develop, implement, and assess
the use of novel research designs and measures, and extend the application
of new theoretical and analytic approaches to suicide prevention and intervention
research; create a “Prevention Research Incubator” (PRI; “Incubator”) to
foster the development of rigorous research that builds upon the ‘natural
opportunities’ that now are arising; and, carry out high quality investigations
that move forward efforts to reduce the mortality and morbidity of suicide,
attempted suicide, and related antecedent conditions.